School of Human and Social Sciences


Tomschi F, Hilberg T. (2024) Response – Reliability and measurement error of exercise-induced hypoalgesia. Scandinavian Journal of Pain. 24(1): 20240044. doi: 10.1515/sjpain-2024-0044.

Tomschi F*,  Brühl M*, Schmidt A, Ransmann P, Strauss AC, Hilberg T. (2024) Functional Clinical Motor Performance Tests to Assess Potential Fall Risks in Patients with Haemophilia: A Case-Control Study. Haemophilia. Online ahead of print. doi: 10.1111/hae.15060. * Contributed equally

Hasenberg T (Herausgeber), Hilberg T (Herausgeber). (2024) Bewegungstherapie bei Adipositas und metabolischem Syndrom. Urban & Fischer Verlag/Elsevier GmbH. ISBN: 9783437230264

Tomschi F*, Schmidt A*, Soffner M, Hilberg T. (2024) Hypoalgesia after aerobic exercise in healthy subjects: A systematic review and meta-analysis. Journal of Sports Sciences. 1–15. doi: 10.1080/02640414.2024.2352682. * Contributed equally

Stephan H, Klophaus N, Wehmeier UF, Tomschi F, Hilberg T (2024) Calculation of oxygen uptake during ambulatory cardiac rehabilitation. J. Clin. Med. 2024, 13, 2235. doi: 10.3390/jcm13082235 (Special Issue New Insights from Cardiopulmonary Exercise Testing and Cardiac Rehabilitation—Part II).

Tomschi F, Schulz J, Stephan H, Hilberg T. (2024) Short all-out isokinetic cycling exercises of 90 and 15 seconds unlock exercise-induced hypoalgesia. European Journal of Pain. 00:1–11. doi: 10.1002/EJP.2276

Schmidt A, Sigl-Kraetzig M, Richter H, Vogler T, Tomschi F, Hilberg T. (2024) Structural alterations on pain perception at the ankle in patients with haemophilia – a prospective controlled study. Haemophilia. 30(3):827-835. doi: 10.1111/hae.15011.

Ransmann P*, Tomschi F*, Schmidt A, Brühl M, Hilberg T. (2024) Paradox pain sensitivity using cuff pressure or algometer testing in patients with haemophilia. Scandinavian Journal of Pain. 24: 20230128. doi: 10.1515/sjpain-2023-0128 * Contributed equally

Klophaus N, Wehmeier UF, Forstner J, Jansen A, Probst H, Grüter S, Hilberg T. (2024). The Impact of Medical Face Masks and Rehabilitation Duration on the Performance Output and Outcomes of Cardiologic Rehabilitants. J. Clin. Med., 13, 1086. (Special Issue: Exercise and Sports Cardiology)

Tomschi F, Hmida J, Herzig S, Ransmann P, Brühl M, Schmidt A, Herzig M, Goldmann G, Strauß A, Oldenburg J, Richter H, Hilberg T. (2024) Physical activity and factor VIII levels in patients with haemophilia: A real-world prospective observational study. Haemophilia, 30:419–425. doi: 10.1111/hae.14965

Tomschi F, Herzig S, Hilberg T. (2024) Rowing and pain: Does rowing lead to exercise induced hypoalgesia? Applied Physiology, Nutrition, and Metabolism, 49(5): 626-634. doi: 10.1139/apnm-2023-0346


Wehmeier UF, Orth V, Höppe V, Valentino LA, Hilberg T. (2023) Neuroinflammatory markers in patients with haemophilia and healthy controls: Where are the differences? Haemophilia, first published online on 03 october 2023,; print version : Haemophilia 29:1539–1546

Brühl M, Hmida J, Tomschi F, Cucchi D, Wirtz DC, Strauß AC, Hilberg T. (2023) Smartphone Use—Influence on Posture and Gait during Standing and Walking. Healthcare, 11, 2543, doi:

Hmida J, Tomschi F*, Strauß AC, Hilberg T*. (2023) Relationship between foot pressure and spinal parameters in healthy adults – A systematic review. Gait & Posture, 103, 126-132. * Contributed equally. doi:

Stephan H, Wehmeier UF, Förster T, Tomschi F, Hilberg T. (2023) Additional active movements are not required for strength gains in the untrained during short-term whole-body electromyostimulation training. Healthcare, 11(5):741. doi: 10.3390/healthcare11050741

Tomschi F, Kieckbusch L, Zachow J, Hilberg T. (2023) Does Exercise-Induced Hypoalgesia Depend on Exercise Duration? Biology, 12, 222. doi:


Noone S, Schubert R, Fichtlscherer S, Hilberg T, Alesci S, Miesbach W, Klophaus N, Wehmeier UF. (2022) Endothelial dysfunction and atherosclerosis related miRNA expression in patients with haemophilia. doi: 10.1111/hae.14658. Online ahead of print

Tomschi F, Lieverkus D, Hilberg T. (2022) Exercise-induced hypoalgesia (EIH) in response to different exercise intensities. European Journal of Applied Physiology; accepted for publication; doi: 10.1007/s00421-022-04997-1

Stephan H, Hagedorn T, Wehmeier UF, Tomschi F, Hilberg T. (2022) Acute Effect of Electromyostimulation Superimposed on Running on Maximal Velocity, Metabolism, and Perceived Exertion. Biology; 11(4), 593; doi: 10.3390/biology11040593

Hmida J, Hilberg T, Ransmann P, Tomschi F, Klein C, Koob S, Franz A, Richter H, Oldenburg J, Strauss A. (2022) Most subjectively affected joints in patients with haemophilia - what has changed after 20 years in Germany? Haemophilia; doi: 10.1111/hae.14564

Böing-Meßing D, Tomschi F, Cegla T, Hilberg T. (2022) The eEgg: Evaluation of a new device to measure pain. Frontiers in Physiology; 13: doi:10.3389

Roussel N, Chantrain V, Foubert A, Lambert C, Hermans C, Meeus M, Guillaume S, Levouvet F, Krüger S, Hilberg T, Lobet S. (2022) Gaining more insight into ankle pain in haemophilia: A study exploring pain, structural and functional evaluation of the ankle joint. Haemophilia.doi:10.1111/hae.14544

Ransmann P, Krüger S, Hagedorn T, Hilberg T, Roussel N. (2022) The Prevalence of Pain in Patitens with haemophilia: A Systematic Review. Scandinavian Journal of Pain. doi:10.1515

Tomschi F, Ransmann P, Hilberg T. (2022) Aerobic training in patients with haemophilia: A systematic review on safety, feasibility and health effects. Haemophilia.doi:10.1111/hae.14522

Hmida J, Hilberg T, Koob S et al. (2022) Peak pressure during Gait in patients with haemophilia: A controlled cross-sectional study. Gait and Posture; Vol. 93. 10.1016

Tomschi F, Cegla T, Hilberg T (2022) Belastungsinduzierter Kopfschmerz im Leistungssport: Eine Übersicht. Leistungssport. 3/2022 (52)


Hmida J, Hilberg T, Krüger S, Jansen T, Goldmann G, Oldenburg J, Wirtz D, Strauss A. (2021) Changes of static and dynamic spine alignment in patients with severe haemophilia. Haemophilia. 10.1111/hae.14406.

Krüger S, Herzig M, Hilberg T. (2021) Changes in pain profile of patients with haemophilia during 1-year follow-up. Haemophilia. doing:10.1111/hae.14380

Hilberg T, Ransmann P, Hagedorn T. (2021). Sport and venous thromboembolism - Site, accompanying features, symptoms and diagnosis. Dtsch Arztebl Int 2021; 118: 181-7. doi: 10.3238/arztebl.m2021.0021

Nonne S, Schubert R, Fichtlscherer S, Hilberg T, Alesci S, Miesbach W. (2021). Endothelial Function in Patients With Von Willebrand Disease. Clinical and Applied Thrombosis/


Hilberg T, Goldmann G, Oldenburg J. (2020). Gezielte sportmedizinische Betreuung bei seltenen Erkrankungen am Beispiel der Hämophilie. Forum Sanitas. accepted.

Hilberg T, Oldenburg J, Goldmann, G. (2020). Hämophile Arthropathie-Schmerzsyndrome bei Patienten mit Hämophilie. Forum Sanitas. accepted.

Herzig ML, Krüger S, Hilberg T. (2020). A single bout of coordination training does not lead to EIH in young health men - a RCT. Scandinavian Journal of Pain. 21(1) doi:10.1515. sjpain-2020-0036


Mirna M, Lichtenauer M, Wernly B, Paar V, Jung C, Kretzschmar D, Uhlemann M, Franz M, Hoppe UC, Schulze PC, Hilberg T, Adams V, Sponder M, Möbius-Winkler S. (2020). Novel cardiovascular biomarkers in patients with cardiovascular diseases undergoing intensive physical exercise. Panminerva Med. doi: 10.23736/S0031-0808.20.03838-0. [Epub ahead of print].

Wehmeier UF, Schweitzer A, Jansen A, Probst H, Grüter S, Hähnchen S, Hilberg T. (2020). Effects of High Intensity Interval Training in a 3-Week Cardiovascular Rehabilitation: A Randomized Controlled Trial. Clin Rehabil. in press. doi:10.1177/0269215520912302.

Wagner B, Krüger S, Hilberg T, Ay C, Hasenoehrl T, Huber DFX, & Crevenna R. (2020). The effect of resistance exercise on strength and safety outcome for people with haemophilia: A systematic review. Haemophilia. 26(2): 200-215. doi:10.1111/hae.13938.

Krüger S & Hilberg T. (2020). Understanding the pain profile in patients with haemophilia: Impaired descending pain inhibition as measured by conditioned pain modulation. Haemophilia. 26(2): 236-242. doi:10.1111/hae.13939.


Hilberg T. (2019). Synovitis bei Hämophilie: Stadiengerechtes Vorgehen. Dtsch Arztebl International. 116(44): A-2012.

Wagner B, Seuser A, Krüger S, Herzig ML, Hilberg T, Ay C, Hasenöhrl T, Crevenna, R. (2019). Establishing an online physical exercise program for people with hemophilia. Wiener klinische Wochenschrift. 131(21-22): 558-566. doi:10.1007/s00508-019-01548-1.


Kurz E, Herbsleb M, Gabriel HHW, Hilberg T. (2018). Posturographic and ankle muscle activation characteristics in patients with haemophilia. Haemophilia. doi: 10.1111/hae.13650.

Stephan H, Herzig ML, Hagedorn T, Wehmeier UF, Hilberg T. (2018). Overview of Motor Skills in Female Elite Rink Hockey Players. Dtsch Z Sportmed. 2018; 69. 326-332.

Hilberg T. (2018). Programmed Sports Therapy (PST) in people with haemophilia - "sports therapy model for rare diseases". Orphanet Journal of Rare Diseases. 13(38): 1-9. doi: 10.1186/s13023-018-0777-7.

Köberlein-Neu J, Runkel B, Hilberg T. (2018). Cost-utility of a six-month Programmed Sports Therapy (PST) in patients with haemophilia. Haemophilia. 24(3): 385-394. doi: 10.1111/hae.13459. Epub 2018 Mar 30.

Krüger S, Hoffmeister M, Hilberg T. (2018). Pain and structural alterations in knee joints in patients with haemophilia. Haemophilia. 24(4): 657-666. doi: 10.1111/hae.13472.

Krüger S, Boettger MK, Hilberg T. (2018). Somatosensory profile of patients with haemophilia. Haemophilia. 24: 97-103. doi: 10.1111/hae.13370.


Runkel B, Hilberg T. (2017). Follow-up of a 6-month Programmed Sports Therapy (PST) in patients with haemophilia. Hämostaseologie. 24(3):385-394. doi: 10.1111/hae.13459.

Kurz E, Herbsleb M, Grassme R, Anders C, Hilberg T. (2017). Trunk Muscle Activation Characteristics in Patients with Severe Haemophilia. Haemophilia. 23(1): 122-128. doi: 10.1111/hae.13037<font size="4">.</font>

Runkel B, von Mackensen S, Hilberg, T. (2016). RCT - Subjective physical performance and quality of life after a six-month programmed sports therapy (PST) in patients with haemophilia. Haemophilia. 23(1): 144-151. doi: 10.1111/hae.13079.


Wahl P, Wehmeier, UF, Jansen F, Kilian Y, Bloch W, Werner N, Mester J, Hilberg T. (2016). Acute effects of different exercise protocols on the circulating vascular microRNAs -16, -21 and -126 in trained subjects. Front. Physiol. doi: 10.3389/fphys.2016.00643.

Krüger S, Weitz C, Runkel B, Hilberg T. (2016). Pain sensitivity in patients with haemophilia following moderate aerobic exercise intervention. Haemophilia. 22(6): 886–893. doi: 10.1111/hae.13016.

Hilberg T. Arthropathien bei Gerinnungsstörungen am Beispiel der Hämophilie: Möglichkeiten des Sports und der Sporttherapie. In: Prävention und Therapie durch Sport - Band 3: Orthopädie, Rheumatologie, Immunologie, Hrsg.: Knapp G, Mewes N, Reimers C, Elsevier, Urban & Fischer, 2016: 101–11.

Krüger S, Khayat D, Hoffmeister M, Hilberg T. (2016). Pain thresholds following maximal endurance exercise. Eur J Appl Physiol. 2016 Mar;116(3): 535-40.

Möbius-Winkler S, Uhlemann M, Adams V, Sandri M, Erbs S, Lenk K, Mangner N, Mueller U, Adam J, Grunze M, Brunner S, Hilberg T, Mende M, Linke AP, Schuler G. (2016). Coronary Collateral Growth Induced by Physical Exercise: Results of the Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable Coronary Artery Disease (EXCITE) Trial. Circulation. 133(15):1438-48; discussion 1448. doi: 10.1161/CIRCULATIONAHA.115.016442. Epub 2016 Mar 15

Kilian Y, Wehmeier UF, Wahl P, Mester J, Hilberg T, Sperlich B. (2016). Acute response of circulating vascular regulating microRNAs during and after high-intensity and high-volume cycling in children. Front. Physiol. doi:10.3389/fphys.2016.00092.

Hoppe MW, Baumgart C, Hilberg T, Freiwald J, Wehmeier UF (2016). Changes of standard physiological-perceptual markers and circulating microRNAs in response to tennis match-play: a case report of two elite players. J Hum Kinet., 51, 71-81.

Runkel B, Czepa D, Hilberg, T. (2016). RCT of a six-month programmed sports therapy (PST) in patients with haemophilia - Improvement of physical fitnes. Haemophilia. doi: 10.1111/hae.12957 . [Epub ahead of print]].

Wendler S, Otto A, Ortseifen V, Bonn F, Neshat A, Schneiker-Bekel S, Wolf T, Zemke T, Wehmeier UF, Hecker M, Kalinowski J, Becher D, Pühler A. (2016). Comparative proteome analysis of the Actinoplanes sp. SE50/110 grown with maltose or glucose shows minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. J Proteomics. 131:140-8. doi: 10.1016/j.jprot.2015.10.023


Runkel B, Kappelhoff M, Hilberg T. (2015). Complex strength performance in patients with haemophilia - Method development and testing. Hämostaseologie 2015; 35 (Suppl. 1): 12-17.

Krüger S., Hilberg T. (2015) Neuropathic pain in patients with haemophilia, that is the question. Hämostaseologie 2015; 35 (Suppl. 1): 5-9.

Wendler S, Otto A, Ortseifen V, Bonn F, Neshat A, Schneiker-Bekel S, Walter F, Wolf T, Zemke T, Wehmeier UF, Hecker M, Kalinowski J, Becher D, Pühler A. (2015). Comprehensive Proteome Analysis of Actinoplanes sp. SE50/110 Highlighting the Location of Proteins Encoded by the Acarbose and the Pyochelin Biosynthesis Gene Cluster. J Proteomics 125:1–16. doi: 10.1016/j.jprot.2015.04.013


Göhler S, Stäuber F, Brunner A, Czepa , Krüger S, Wendel M, Seuser A, Hilberg T. (2014) Altersabhängige Ansteuerung der Muskulatur im Stand bei Patienten mit Hämophilie. Hämostaseologie 2014; 34 (Suppl 1): S36-42.

Stemberger M, Schmit E, Czepa D, Kurnik K, Spannagl M. (2014). Therapeutisches Klettern unter PK-adaptierter Prophylaxe. Hämostaseologie 2014; 34 (Suppl 1): S13-18.

Wendler S, Ortseifen V, Persicke M, Klein A, Neshat A, Niehaus K, Schneiker-Bekel S, Walter F, Wehmeier UF, Kalinowski J, Pühler A. (2014) Carbon source dependent biosynthesis of acarviose metabolites in Actinoplanes sp. SE50/110. J. Biotechnol. 191:113–120. doi: 10.1016/j.jbiotec.2014.08.019

Czepa D, Hilberg W, Poschmann J, Straaten S, Hilberg T. (2014). Lebensmittelkonsum und Ernährungsverhalten bei Patienten mit Hämophilie vor und nach Ernährungsberatung. Hämostaseologie 2014; 34 (Suppl 1): S43–S47.

Astermark J, Dolan G, Hilberg T, Jiménez-Yuste V, Laffan M, Lassila R, Lobet S, Martinoli C, Perno CF. (2014). Managing haemophilia for life: 4th haemophilia global summit. Haemophilia. 2014 Jul;20 Suppl 5:1-20.

Brunner A, Stäuber F, Göhler S, Czepa D, Wendel M, Seuser A, Hilberg T. (2014).Impact of joint status on contraction steadiness of M. quadriceps femoris in people with severe haemophilia. Haemophilia 20(6):884–890. doi: 10.1111/hae.12493

Wehmeier UF, Hilberg T. (2014).Capillary earlobe blood may be used for RNA isolation, gene expression assays and microRNA quantification. Mol Med Report 9: 211-216.

Uhlemann M, Möbius-Winkler S, Fikenzer S, Adam J, Redlich M, Möhlenkamp S, Hilberg T, Schuler GC, Adams V. (2014) Circulating microRNA-126 increases after different forms of endurance exercise in healthy adults. Eur J Prev Cardiol 21(4):484–491. doi: 10.1177/2047487312467902.


Boettger MK., Krucker S., Gajda M., Schaible HG., Hilberg T. (2013) Repeated autologous intraarticular blood injections as an animal model for joint pain in haemophilic arthropathy. Arthritis Res Ther. 2013 Oct 7;15(5):R148.

Kappenstein J, Ferrauti A, Runkel B, Fernandez-Fernandez J, Müller K, Zange J. (2013) Changes in phosphocreatine concentration of skeletal muscle during high-intensity intermittent exercise in children and adults. Eur J Appl Physiol. 113(11):2769-79. doi: 10.1007/s00421-013-2712-x. Epub 2013 Aug 31.

Czepa D, van Ravenstein S, Stäuber F, Hilberg T. (2013) Entwicklung und Evaluierung einer tanzbasierten Bewegungstherapie für Patienten mit Hämophilie. Hämostaseologie 2013; 33 (Suppl 1): S25–S31.

Brunner A., Stäuber F., Göhler S., Czepa D., Krüger S., Wendel M., Seuser A., Hilberg T. (2013) Quadriceps strength, inter-extremity difference (IED) and joint status in adult persons with severe haemophilia in different age stages. Haemophilia, 19 (2): 267-74.

Czepa D., von Mackensen S., Hilberg T. (2013) Haemophilia & Exercise Project (HEP): The impact of one year sports therapy programme on physical performance in adult haemophilia patients. Haemophilia, 19 (2): 194-9.

Wendler S, Hürtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Pühler A. (2013) The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism. J. Biotechnol. 167(2):178–189. doi: 10.1016/j.jbiotec.2012.08.011.


Hilberg T, Menzel K, Wehmeier UF. (2012). Endurance training modifies exercise-induced activation of blood coagulation: RCT. Eur. J. Appl. Physiol. 113(6):1423–1430. doi: 10.1007/s00421-012-2564-9.

Schwientek P, Wendler S, Neshat A, Eirich C, Rückert C, Klein A, Wehmeier UF, Kalinowski J, Stoye J, Pühler A. (2012). Comparative RNA-sequencing of the acarbose producer Actinoplanes sp. SE50/110 cultivated in different growth media. J. Biotechnol. 167(2):166–177. doi: 10.1016/j.jbiotec.2012.10.019.

Herbsleb M, Abou-Hamdan R, Puta C, Donath L, Kobelt R, Stanek FD, Hilberg T, Gabriel HH. (2012). Severe and moderate haemophilia under prophylactic replacement treatment - Maximal knee extensor and flexor torque of children and adolescents. Hamostaseologie. 2012;32 Suppl 1:S62-9. [Article in German]

Uhlemann M, Adams V, Lenk K, Linke A, Erbs S, Adam J, Thiele H, Hilberg T, Gutberlet M, Grunze M, Schuler GC, Möbius-Winkler S. (2012). Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial. Trials. 2012 Sep 14;13 (1):167.

Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Pühler A. (2012) The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110. BMC Genomics. 13:112.

Parthier C, Gçrlich S, Jaenecke F, Breithaupt C, Bräuer U, Fandrich U, Clausnitzer D, Wehmeier UF, Böttcher C, Scheel D, Stubbs MT. (2012). The O-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction. Angew. Chem. Int. Ed. 51:4046 –4052.

Parthier C, Gçrlich S, Jaenecke F, Breithaupt C, Bräuer U, Fandrich U, Clausnitzer D, Wehmeier UF, Böttcher C, Scheel D, Stubbs MT. (2012). Die O-Carbamoyltransferase TobZ katalysiert eine enzymatische Reaktion frühen Ursprungs. Angew. Chem. 124:4122 –4128.

Czepa D, von Mackensen S, Hilberg T. (2012) Haemophilia & Exercise Project (HEP): subjective and objective physical performance in adult haemophilia patients – results of a cross-sectional study. Haemophilia, 18 (1): 80-5.

Kurz E, Anders C, Herbsleb M, Puta C, Czepa D, Hilberg T (2012) Ankle muscle activation in people with haemophilia. Haemophilia 18(6):948–954. doi: 10.1111/j.1365-2516.2012.02852.


Hilberg T., Czepa D., Freialdenhoven D., Boettger M. K. (2011) Joint pain in people with hemophilia depends on joint status. Pain, 152 (9): 2029-35.

Kurz E, Herbsleb M, Anders C, Puta C, Vollandt R, Czepa D, Ziezio R, Scholle HC, Hilberg T. (2011) SEMG activation patterns of thigh muscles during upright standing in haemophilic patients. Haemophilia, 17 (4): 669-75.

Clausnitzer D., Piepersberg W., Wehmeier UF.(2011). The oxidoreductases LivQ and NeoQ are responsible for the different 6`-modifications in the aminoglycosides lividomycin and neomycin. J. Appl. Microbiol. 111(3):642-651.

Menzel K., Hilberg T. (2011). Blood coagulation and fibrinolysis in healthy, untrained subjects: effects of different exercise intensities controlled by individual anaerobic threshold. Eur J Appl Physiol. 111:253-60.

Licht A, Bulut H, Scheffel F, Daumke O, Wehmeier UF, Saenger W, Schneider E, Vahedi-Faridi A. (2011). Crystal Structures of the Bacterial Solute Receptor AcbH Displaying an Exclusive Substrate Preference for β-d-Galactopyranose. J Mol Biol. 406:92-105.

Coll Barosso M, Nickl W, Schumacher C, Hilberg T, Wehmeier UF, Scheffold T, Füth R, Lankisch M, Lukic I, Dinh W. (2011). Systemvaskulärer Widerstand vor und nach körperlicher Belastung bei Patienten mit diastolischer Herzinsuffizienz. Deutsche Zeitschrift für Sportmedizin 62: 16-21.


Herbsleb M, Tutzschke R, Czepa D, Gabriel HHW, Hilberg T. (2010) Isometrische Maximalkraftmessungen der Quadrizepsmuskulatur. Durchführbarkeit und Reliabilität bei Patienten mit Hämophilie. Hämostaseologie, 30 (Suppl 1): S97-S103.

Vahedi-Faridi A, Licht A, Bulut H, Scheffel F, Keller S, Wehmeier UF, Saenger W, Schneider E. (2010). Crystal structures of the solute receptor GacH of Streptomyces glaucescens in complex with acarbose and an acarbose homolog: comparison with the acarbose-loaded maltose-binding protein of Salmonella typhimurium. J Mol Biol. 397:709-723.

Von Mackensen S, Czepa D, Herbsleb M, Hilberg T. (2010) Development and validation of a new questionnaire for the assessment of subjective physical performance in adult patients with haemophilia - the HEP-Test-Q. Haemophilia, 16:170-178.


Moebius-Winkler S., Hilberg T., Menzel K., Golla E., Burman A., Schuler G., Adams V. (2009). Time Dependent Mobilization of Circulating Progenitor Cells During Strenuous Exercise in Healthy Individuals. J Appl Physiol. 107:1943-1950

Wehmeier U.F. and Piepersberg W. (2009). Enzymology of Aminoglycoside Biosynthesis – Deduction from Gene Clusters. Methods in Enzymology volume 459: 457-489

Claus R., Bockmeyer C., Budde U., Kentouche K., Sossdorf M., Hilberg T., Schneppenheim R., Reinhart K., Bauer M., Brunkhorst F. M., Lösche W. (2009). Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure. Thromb Haemost. 2009 Feb;101:239-247. [pubmed]

Piepersberg W. and Wehmeier U. F. (2009). Aminoglycosides, Bioactive Bacterial Metabolites. M. Schaechter (editor): Encyclopedia of Microbiology, 3rd edition, chapter 38. Elsevier Inc., San Diego, USA.


Menzel K., Hilberg T. (2008). Coagulation and Fibrinolysis are in Balance After Moderate Exercise in Middle-aged Participants. Clin Appl Thromb Hemost. 15:348-355. [pubmed]

Herbsleb M., Hilberg T. (2008). Maximal and submaximal endurance performance in adults with severe haemophilia. Haemophilia. 15:114-121. [pubmed]

Hilberg T. (2008). Physical activity in the prevention of cardiovascular diseases. Epidemiology and mechanisms. Hamostaseologie. 28:9-15. [pubmed]

Czepa D., Herbsleb M., Ziezio R., Kurz E. & Hilberg T. (2008). Haemophilia and Exercise Project (HEP): Gelenkstatus und Lebensqualität vor und nach einer zweijährigen Sporttherapie. Deutsche Zeitschrift für Sportmedizin, 59:62-67. [Dtsch. Z. Sportmed.]

Rockser Y. and Wehmeier U. F. (2008). The gac-gene cluster from Streptomyces glaucescens identification, isolation and characterization. J. Biotechnol. Nov 18. [Epub ahead of print]

Hilberg T., Menzel K., Gläser D., Zimmermann S. & Gabriel, H. (2008). Exercise intensity: Platelet function and platelet-leukocyte conjugate formation in untrained subjects -. Thromb Res, 122, 77-84. [pubmed]


Hilberg T. (2007). Etiology of exercise-induced asthma: physical stress-induced transcription. Curr Allergy Asthma Rep. 2007 Apr;7(1):27-32. [pubmed]

Piepersberg W., Aboshanab K., Schmidt-Beißner H. and Wehmeier U. F. (2007). Molecular Biology and Evolution of Aminoglycoside Producers. In D. P. Arya (editor): Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery, pp. 15-118. Wiley and Sons, New Jersey, USA (ISBN-13: 978-0471743026 )


Claus R. A., Bockmeyer C. L., Sossdorf M., Lösche W. & Hilberg T. (2006). Physical stress as a model to study variations in ADAMTS 13 activity, von Willebrand factor level and platelet activation. J Thromb Haemost, 4(4), 902-905. [pubmed]

Gläser D. & Hilberg T. (2006). The influence of bromelain on platelet count and platelet activity in vitro. Platelets, 17(1), 37-41. [pubmed]

Schmidt V. & Hilberg T. (2006). ThromboFix platelet stabilizer: Advances in clinical platelet analyses by flow cytometry? Platelets, 17(4), 266-273. [pubmed]


Hilberg T., Gläser D., Prasa D., Stürzebecher J. & Gabriel H. (2005). Pure eccentric exercise does not activate blood coagulation. European Journal of Applied Physiology, 94(5-6), 718-721. [pubmed]

Hilberg T. (2005). Sport bei Blutungsneigung. Deutsche Zeitschrift für Sportmedizin, 56, 365-366. [Dtsch. Z. Sportmed.]

Hilberg T. (2005). Thrombozytenaktivität und Thrombozyten-Leukozyten-Konjugate als Marker in der Sportmedizin. Journal of Laboratory Medicine, 29(5), 384-392.

Hilberg T., Deigner H. P., Möller E., Claus R. A., Ruryk A., Gläser D., et al. (2005). Transcription in response to physical stress--clues to the molecular mechanisms of exercise-induced asthma. The FASEB Journal, 19(11), 1492-1494. [pubmed]

Brunkhorst C., Wehmeier U.F., Piepersberg W., Schneider E. (2005). The acbH gene of Actinoplanes sp. encodes a solute receptor with binding activities for acarbose and longer homologs. Res. Microbiol. 156:322-327

Wehmeier U.F. (2005). Concanamycin A - ein interessant garniertes Polyketid. GenomXpress Sonderausgabe September 2005 (ISSN 1617-562X), 19-20


Hilberg T., Eichler E., Gläser D., Schmidt V. & Gabriel H. (2004). Platelet activity, reactivity and platelet-leukocyte conjugate formation before and after exhaustive or moderate exercise in patients with IDDM. Platelets, 15(2), 101-108. [pubmed]

Hilberg T., Gläser D., Koksch M., Schmidt V., Sossdorf M. & Gabriel H. (2004). Differentiation of platelet-leukocyte conjugate formation by short term exercise. Clinical Hemorheology and Microcirculation, 31(3), 217-226. [pubmed]

Hilberg T. & Gabriel H. (2004). Tromboseneigung bei Sportlern. Deutsche Zeitschrift für Sportmedizin, 55, 79-80. [Dtsch. Z. Sportmed.]

Leemhuis H., Wehmeier U.F., Dijkhuizen L. (2004). Single Amino Acid Mutations Interchange the Reaction Specificities of Cyclodextrin Glycosyltransferase and the Acarbose Modifying Enzyme Acarviosyl Transferase. Biochemistry 43:13204-13213.

Wehmeier U.F. (2004). Acarbose- ein therapeutisch eingesetzter Wirkstoff: Biosynthese und Funktion. Biospektrum 1/2004:34-36.

Wehmeier U.F. and Piepersberg W. (2004). Molecular Biology and Enzymology of the Metabolism of the a-Glucosidase Inhibitor Acarbose. Appl. Microbiol. Biotechnol. 63:613-625.


Hilberg T., Eichler E., Gläser D., Prasa D., Stürzebecher J. & Gabriel H. (2003). Blood coagulation and fibrinolysis before and after exhaustive exercise in patients with IDDM. Thrombosis and Haemostasis, 90(6), 1065-1073. [pubmed].

Hilberg,T., Gläser D., Reckhart C., Prasa D., Stürzebecher J. & Gabriel H. (2003). Blood coagulation and fibrinolysis after long-duration treadmill exercise controlled by individual anaerobic threshold. European Journal of Applied Physiology, 90(5-6), 639-642. [pubmed]

Hilberg T., Gläser D., Schmidt V., Losche W., Franke G., Schneider K., et al. (2003). Short-term exercise and platelet activity, sensitivity to agonist, and platelet-leukocyte conjugate formation. Platelets, 14(2), 67-74. [pubmed]

Hilberg T., Herbsleb M., Puta C., Gabriel H. & Schramm W. (2003). Körperliches Training steigert die isometrische Muskelkraft und sensomotorische Fähigkeiten bei hämophilen Personen. Deutsche Zeitschrift für Sportmedizin, 54, 281-287. [Dtsch. Z. Sportmed.]

Hilberg T., Herbsleb M., Puta C., Gabriel H. & Schramm W. (2003). Physical training increases isometric muscular strength and proprioceptive performance in haemophilic subjects. Haemophilia, 9(1), 86-93. [pubmed]

Hilberg T., Prasa D., Stürzebecher J., Gläser D., Schneider K. & Gabriel H. (2003). Blood coagulation and fibrinolysis after extreme short-term exercise. Thrombosis Research, 109(5-6), 271-277. [pubmed]

Hilberg T., Schmidt V., Lösche W. & Gabriel H. (2003). Platelet activity and sensitivity to agonists after exhaustive treadmill exercise. Journal of Sports Science and Medicine, 2, 15-22.

Schmidt V., Hilberg T., Franke G., Gläser D. & Gabriel H. (2003). Paraformaldehyde fixation induces a systematic activation of platelets. Platelets, 14(5), 287-294. [pubmed]

Wehmeier U.F. (2003). The Biosynthesis and Metabolism of Acarbose in Actinoplanes SE50/110: A Progress Report. Biocat. Biotrans. 21:279-285

Zhang C.S., Podeschwa M., Altenbach H.J., Piepersberg W., Wehmeier U.F. (2003). The Acarbose-Biosynthetic Enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-Valiolone-7-phosphate 2-Epimerase. FEBS Lett. 540:47-52

Zhang C.S., Podeschwa M., Block O., Altenbach H.J., Piepersberg W., Wehmeier, U.F. (2003). Identification of a 1-epi-Valienol 7-Kinase Activity in the producer of Acarbose, Actinoplanes sp. SE 50/110. FEBS Lett. 540:53-57


Hilberg T., Schmidt V., Gläser D., Schammne D., Losche W. & Gabriel H. (2002). Platelet activity, sensitivity to agonist, and platelet--leukocyte conjugate formation after long-term exercise. Platelets, 13(5-6), 273-277. [pubmed]

Hilberg T., Jeschke D. & Gabriel H. (2002). Hereditary thrombophilia in elite athletes. Medicine & Science in Sports & Exercise, 34(2), 218-221. [pubmed]

Hilberg T., Prasa D., Stürzebecher J., Gläser D. & Gabriel H. (2002). Thrombin potential and thrombin generation after exhaustive exercise. International Journal of Sports Medicine, 23(7), 500-504. [pubmed]

Zhang C.S., Stratmann A., Block O., Bruckner R., Podeschwa M., Altenbach H.J., Wehmeier U.F., Piepersberg, W. (2002). Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway. J. Biol. Chem. 277:22853-22862

Piepersberg W., Diaz-Guardamino Uribe P.M., Stratmann A., Thomas H., Wehmeier U., Zhang C.S. (2002). Recent Developments in the Biosynthesis and Regulation of Aminoglycosides. In: Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation, edited by Francisco Fierro and Juan Francisco Martín. pp. 1-26, Research Signpost, Kerala, India.


Hilberg T., Herbsleb M., Gabriel H., Jeschke D. & Schramm W. (2001). Proprioception and isometric muscular strength in haemophilic subjects. Haemophilia, 7(6), 582-588. [pubmed]

Wehmeier U. F. (2001). Molecular cloning, nucleotide sequence and structural analysis of the Streptomyces galbus DSM40480 fda gene: The S. galbus fructose-1,6-bisphosphate aldolase is a member of the class II aldolases. FEMS Microbiol. Lett. 197:53-58

Albermann C., Piepersberg W., Wehmeier U.F. (2001). Synthesis of the milk oligosaccharide 2´-fucosyllactose using recombinant bacterial enzymes. Carbohydr. Res. 334:97-103


Hilberg T., Nowacki P. E., Müller-Berghaus G. & Gabriel H. (2000). Changes in blood coagulation and fibrinolysis associated with maximal exercise and physical conditioning in women taking low dose oral contraceptives. Journal of Science and Medicine in Sport, 3(4), 383-390. [pubmed]

Doumith M., Weingarten P., Wehmeier U.F., Salah-Bey K., Benhamou B., Capdevila C., Michel J.-M., Piepersberg W., Raynal M.-C. (2000). Analysis of genes involved in the 6-deoxyhexose biosynthesis and transfer in Saccharopolyspora erythraea. Mol. Gen. Genet. 264:477-485


Hilberg T. & Jeschke D. (1999). Erythropoietin: Vom Medikament zum Dopingmittel. Sportorthopädie - Sporttraumatologie, 15, 13-16.

Pöhling S., Piepersberg W, Wehmeier U.F. (1999). Analysis and regulation of the secY gene from Streptomyces griseus N2-3-11 and interaction of the SecY protein with the SecA protein. Biochim. Biophys. Acta. 1447:298-302


Hilberg T., Moessmer G., Hartard M. & Jeschke D. (1998). APC resistance in an elite female athlete. Medicine & Science in Sports & Exercise, 30(2), 183-184. [pubmed]


Hartard M., Hilberg T., Jeschke D., Haber P., Preisinger E., Seidl G., et al. (1997). Systematisches Krafttraining als Modell therapeutischer Intervention- Osteopenie. Österreichische Zeitschrift für Physikalische Medizin und Rehabilitation, 7(Suppl 1), 33-36.

Pöhling S., Piepersberg W., Wehmeier U.F. (1997). Protein Secretion in Streptomyces griseus N2-3-11: Cloning, Sequencing, and functional Characterization of the secA gene and its growth phase-dependent expression. FEMS Microbiol. Lett. 156:21-29

Hartard M., Hilberg T. & Jeschke D. (1997). Systematisches Ausdauertraining als Modell therapeutischer Intervention - Hypertonie. Österreichische Zeitschrift für Physikalische Medizin und Rehabilitation, 7(Suppl 1), 18-21

vor 1997

Mehling A., Wehmeier U.F., Piepersberg W. (1995). Nucleotide sequences of streptomycete 16S ribosomal DNA: towards a specific identification system for streptomycetes using PCR. Microbiology 141: 2139-47

Mehling A., Wehmeier U.F., Piepersberg W. (1995). Application of random amplified polymorphic DNA (RAPD) assays in identifying conserved regions of actinomycete genomes. FEMS Microbiol. Lett. 128: 119-25

Wehmeier U.F. (1995). New multifunctional Escherichia coli-Streptomyces shuttle vectors allowing blue-white screening on X-gal plates. Gene 165:149-150

Wehmeier U.F., Wöhrl B.M., Lengeler J.W. (1995). Molecular analysis of the phosphoenolpyruvate-dependent L-sorbose: phosphotransferasesystem from Klebsiella pneumoniae and of its multidomain structure. Mol. Gen. Genet. 246:610-618

Lengeler J.W., Jahreis K., Wehmeier U.F. (1994). Enzymes II of the phosphoenolpyruvate-dependent phosphotransferase systems: their structure and function in carbohydrate transport. Biochim. Biophys. Acta 1188:1-28

Wehmeier U.F., Lengeler J.W. (1994). Sequence of the sor-operon for L-sorbose utilization from Klebsiella pneumoniae KAY2026. Biochim. Biophys. Acta 1208:348-51

Wehmeier U.F., Nobelmann B., Lengeler J.W. (1992). Cloning of the Escherichia coli sor genes for L-sorbose transport and metabolism and physical mapping of the genes near metH and iclR. J. Bacteriol. 174:7784-90

Wöhrl B.M., Wehmeier U.F, Lengeler J.W. (1990). Positive and negative regulation of expression of the L-sorbose (sor) operon by SorC in Klebsiella pneumoniae. Mol. Gen. Genet. 224:193-200

Wehmeier U., Lengeler J.W. (1989). Verwendung chromosomaler lacZ Fusionen bei Klebsiella pneumoniae zur Genkartierung und für Regulationsstudien beim sor-Operon. Biol. Chem. Hoppe-Seyler 370:972

Wehmeier U., Sprenger G.A., Lengeler J.W. (1989). The use of lambda plac-Mu hybrid phages in Klebsiella pneumoniae and the isolation of stable Hfr strains. Mol. Gen. Genet. 215: 529-36

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